Ambrisentan
Generic name: ambrisentan [ AM-bri-SEN-tan ]
Brand name: Letairis
Dosage form: oral tablet (10 mg; 5 mg)
Drug class:Agents for pulmonary hypertension
What is ambrisentan?
Ambrisentan lowers blood pressure in your lungs, helping your heart pump blood more efficiently.
Ambrisentan is used to treat pulmonary arterial hypertension (PAH) in adults. It improves your ability to exercise and prevents your condition from getting worse. Ambrisentan is sometimes used with a medicine called tadalafil (Adcirca).
For women, ambrisentan is available only from a certified pharmacy under a special program. You must be registered in the program and sign agreements to use birth control and undergo pregnancy and blood testing.
Ambrisentan may also be used for purposes not listed in this medication guide.
Warnings
Do not use if you are pregnant or think you might be pregnant. You will need to take a pregnancy test before, during, and after treatment with ambrisentan. Use highly effective birth control while using ambrisentan and for at least 30 days after your last dose.
You should not use ambrisentan if you have idiopathic pulmonary fibrosis.
Before taking this medicine
You should not use ambrisentan if you are allergic to it, or if you have idiopathic pulmonary fibrosis (IPF).
Do not use ambrisentan if you are pregnant or think you might be pregnant. This medicine can cause serious birth defects. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant.
You will need to have a negative pregnancy test before starting this treatment. You will be re-tested every month during your treatment, and 1 month after your last dose.
Even if you are not planning a pregnancy, you are considered able to become pregnant if:
you have entered puberty (even if you have not yet started having periods);
you have never had a hysterectomy or had your ovaries removed; or
you have not gone through menopause (you have never gone 12 months in a row without a menstrual period).
While taking ambrisentan and for at least 30 days after your last dose, you must use a highly effective form of birth control or two methods together.
Recommended forms of birth control forms include:
a tubal ligation, or a copper IUD (intrauterine device) or pro...
