Kcentra

Generic name:prothrombin complex [ pro-THROM-bin-KOM-plex ]
Drug class:Anticoagulant reversal agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 12, 2022.

What is Kcentra?

Kcentra is a blood coagulation factor replacement product.

Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.

Kcentra is for use in adults and dosing is based on body weight.

Warnings

While using Kcentra, tell your caregivers right away if you have signs of a blood clot: sudden numbness or weakness, problems with vision or speech, chest pain, cough, wheezing, rapid breathing, swelling or pain in your arms, legs, or stomach.

Tell your doctor if you have ever had a heart attack, stroke, TIA or "mini-stroke", chest pain, severe circulation problems, or a blood clot (especially within the past 3 months).

Kcentra is for use in people who use blood thinners such as warfarin. After you are treated with this medicine, do not start using your blood thinner again until your doctor tells you to.

Before taking this medicine

You should not be treated with Kcentra if you have:

• low levels of platelets in your blood after using heparin;

• excessive blood-clotting caused by a condition called disseminated intravascular coagulation; or

• a history of severe allergic reaction to prothrombin complex, Protein C or Protein S, Antithrombin III, heparin, human albumin, or Factors II, VII, IX, X.

If possible before you receive Kcentra, tell your caregivers if you have ever had:

• a stroke, including TIA (transient ischemic attack) or "mini-stroke";

• a heart attack;

• disseminated intravascular coagulation;

• severe circulation problems;

• chest pain (angina); or

• if you have had a blood-clot within the last 3 months.

Tell your doctor if you are pregnant or breastfeeding.

Kcentra is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

How is Kcentra given?

Kcentra is given as an infusion into a vein. A healthcare provider will give you this injection.

After you are treated with Kcentra, do not start using your blood thinner again until your doctor tells you to.

In case of emergency, wear or carry medical identification to let others know you use a blood thinner.

Dosing information

Usual Adult ...