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Amifampridine
  • Treatments
  • Lambert-Eaton Myasthenic Syndrome

Amifampridine

Generic name: amifampridine [ AM-i-FAM-pri-deen ]
Brand name: Firdapse
Dosage form: oral tablet (10 mg)
Drug class:Cholinergic muscle stimulants

Medically reviewed by Drugs.com on Jan 24, 2022. Written by Cerner Multum.

What is amifampridine?

Amifampridine is used to treat Lambert-Eaton myasthenic syndrome in adults.

Amifampridine may also be used for purposes not listed in this medication guide.

Warnings

Amifampridine can cause seizures, even if you have never had a seizure in the past. Stop taking amifampridine and call your doctor right away if you have a seizure.

Before taking this medicine

You should not use amifampridine if you are allergic to it, or if:

  • you have had a seizure in the past; or

  • you are allergic to dalfampridine.

Tell your doctor if you have ever had:

  • a seizure;

  • liver disease;

  • kidney disease; or

  • if you also take a form of amifampridine obtained from a compounding pharmacy (3,4-diaminopyridine or 3,4-DAP).

Tell your doctor if you are pregnant or breast-feeding.

How should I take amifampridine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take amifampridine with or without food.

Do not take more than 2 tablets at one time. Do not take more than 8 tablets in 24 hours.­

The amifampridine tablet may be split in half if needed.

Store at room temperature away from moisture and heat.

Throw away any amifampridine not used before the expiration date on the medicine label.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amifampridine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Amifampridine side effects

Get emergency medical help if you have signs of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amifampridine can cause seizures, even if you have never had a seizure in the past.

Stop using amifampridine and call your doctor at o...