Ledipasvir and sofosbuvir
Generic name: ledipasvir and sofosbuvir [ le-DIP-as-vir-and-soe-FOS-bue-vir ]
Brand name: Harvoni
Dosage forms: oral pellet (33.75 mg-150 mg; 45 mg-200 mg); oral tablet (45 mg-200 mg; 90 mg-400 mg)
Drug class:Antiviral combinations
What is ledipasvir and sofosbuvir?
Ledipasvir and sofosbuvir is a combination medicine used to treat chronic hepatitis C in adults and children who are at least 3 years old. Ledipasvir and sofosbuvir is sometimes given in combination with another medicine called ribavirin.
Ledipasvir and sofosbuvir treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.
Ledipasvir and sofosbuvir is sometimes used in people who also have HIV. ledipasvir and sofosbuvir is not a treatment for HIV or AIDS.
Ledipasvir and sofosbuvir may also be used for purposes not listed in this medication guide.
Warnings
If you've ever had hepatitis B, it may become active or get worse while using or after you stop using ledipasvir and sofosbuvir. You may need frequent liver function tests for several months.
Ledipasvir and sofosbuvir is sometimes used in combination with other medication. Read the medication guide or patient instructions provided with each medication in your combination therapy. Do not change your doses or medication schedule without your doctor's advice.
Before taking this medicine
You should not use ledipasvir and sofosbuvir if you are allergic to ledipasvir or sofosbuvir. If you take ledipasvir and sofosbuvir with ribavirin: There may be other reasons you should not take this combination treatment. Tell your doctor about all your medical conditions.
Tell your doctor if you have ever had:
hepatitis B (you may be tested for this before you take sofosbuvir);
liver problems other than hepatitis (including a liver transplant);
kidney disease (or if you are on dialysis);
HIV or AIDS;
a heart rhythm problem for which you take a medicine called amiodarone; or
if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.
Ledipasvir and sofosbuvir is sometimes used in combination with ribavirin. Both men and women using ribavirin should use effective birth control to prevent pregnancy...
