LexiCaps Patch

Generic name: levomenthol and capsaicin
Dosage form: patch

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

PRESCRIBER INFORMATION

LexiCapsPatch®(Menthol 5% / Capsaicin 0.025% Topical Patch)

DESCRIPTION:

LexiCaps Patch® is a prescription topical patch containing 15 articulated LexiCaps Patches (5 per re-sealable pouch x 3 pouches). Capsaicin is present in a 0.025% concentration (w/w). It is chemically designated as (E)-N-[(4-Hydroxy-3-methoxyphenyl) methyl]-8-methylnon-6-enamide and has an empirical formula of C18H27NO3. The molecular weight of capsaicin is 305.41 g/mol. Menthol is present in a 5% concentration (w/w). The chemical name is (1R,2S,5R)-2-isopropyl-5-methylcyclohexanol. The empirical formula for menthol is C10H20O with a molecular weight of 156.27 g/mol.

The structural formulas are:

** Menthol **

** Capsaicin**

CLINICAL PHARMACOLOGY:

Capsaicin is an active component of chili peppers known clinically as a rubefacient. It acts as a counter-irritant by producing heat when in contact with human tissue. Mechanistically, capsaicin exerts its analgesic and anti-inflammatory effects by mimicking a burning sensation – whereby overwhelming the nerves by calcium influx, thereby rendering the nerves unable to signal a pain response for an extended period of time. With repeated exposure, the neurons become depleted of neurotransmitters –specifically substance ...