Lido-K Lotion

Generic name:lidocaine hydrochloride
Dosage form: lotion
Drug class:Topical anesthetics

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Topical Anesthetic

For external use only.
Not for ophthalmic use.

Rx only

Lido-K Lotion Description

Contains Lidocaine Hydrochloride. Lidocaine is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl), and has the following structure:

C14H22N2O

Each mL of Lido-K Lotion contains ACTIVE: Lidocaine HCl 30 mg in a lotion base of INACTIVES: Mineral Oil, Petrolatum, Cetyl Alcohol, Stearic Acid, Methylparaben, Propylparaben, Lexemul, Water, Sodium Hydroxide (50%), Aluminum Sulfate, and Calcium Acetate

Lido-K Lotion - Clinical Pharmacology

MECHANISM OF ACTION

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for initiation and conduction of impulses, thereby effecting local anesthetic action.

PHARMACOKINETICS

Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of application, duration of exposure, concentration and total dosage. In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug appears in the circulation because of biotransformation in the liver.

Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological /..