Lidocaine and Hydrocortisone Cream

Generic name: lidocaine hydrochloride and hydrocortisone acetate
Dosage form: cream
Drug class:Topical anesthetics

Medically reviewed by Drugs.com. Last updated on Jan 1, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Read further information about unapproved drugs.

DESCRIPTION:

Anti-Inflammatory Anesthetic for Relief of Hemorrhoid Pain, Swelling and Inflammation.
Lidocaine is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl), and has the following structure:

Hydrocortisone acetate has a chemical name pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-(11β)-, and has the following structural formula:

PharmaPure Rx Lidocaine HCl 3% - Hydrocortisone Acetate 0.5% CreamEach gram contains Lidocaine HCl 30 mg, Hydrocortisone Acetate 5 mg.

ACTIVE INGREDIENTS:
LIDOCAINE HCl 3%
HYDROCORTISONE ACETATE 0.5%

INACTIVE INGREDIENTS:

ALUMINUM SULFATE, CALCIUM ACETATE, CETYL ALCOHOL, METHYLPARABEN, MINERAL OIL, POLYSORBATE 60, PROPYLENE GLYCOL, PROPYLPARABEN, PURIFIED WATER, SODIUM HYDROXIDE, SORBITAN STEARATE, STEARIC ACID, STEARYL ALCOHOL.

CLINICAL PHARMACOLOGY:

MECHANISM OF ACTION:

Product releases lidocaine to stabilize the neuronal membrane by inhibiting the ionic fluxes required for initiation and conduction of impulses, thereby effecting local anesthetic action. Hydrocortisone acetate provides relief of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

PHARMACOKINETICS:

Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of application, duration of exposure, concentration, and total dosage. In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug appears in the circulation be