Lidocaine and Hydrocortisone Rectal Cream
Generic name: lidocaine hydrochloride, hydrocortisone acetate
Dosage form: rectal cream
Drug class:Topical anesthetics
Medically reviewed by Drugs.com. Last updated on Feb 1, 2022.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Read further information about unapproved drugs.
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Anti-Inflammatory Anesthetic for Relief of Hemorrhoid Pain, Swelling and Inflammation
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DESCRIPTION:
Lidocaine 3% - Hydrocortisone 1% Cream Kit are indicated for the anti-inflammatory and anesthetic relief of itching, pain, soreness, and discomfort due to hemorrhoids, anal fissures, pruritus ani and similar conditions of the anal area.
ACTIVE INGREDIENTS:
Lidocaine 3% - Hydrocortisone 1% Cream Kit
lidocaine hydrochloride 3% (30mg) and hydrocortisone acetate 1% (10 mg) per gram.
INACTIVE INGREDIENTS:
aluminum sulfate, calcium acetate, carbomer 980, cetyl alcohol, citric acid, glycerine, methylparaben, mineral oil, polycarbophil, propylene glycol, propylparaben, purified water, sodium citrate, sodium lauryl sulfate, sodium hydroxide, sorbitan stearate, stearic acid, stearyl alcohol, trolamine, urea, and white petrolatum.
CLINICAL PHARMACOLOGY:
MECHANISM OF ACTION:
Product releases lidocaine to stabilize the neuronal membrane by inhibiting the ionic fluxes required for initiation and conduction of impulses, thereby effecting local anesthetic action. Hydrocortisone acetate provides relief of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Lidocaine is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl), and has the following structure:
Hydrocortisone acetate has a chemical name pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11,17- dihydroxy-(11ß)-. It has the following structural formula:
PHARMACOKINETICS:
Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of ap...
