Locoid Solution

Generic name:hydrocortisone butyrate
Dosage form: topical solution
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

FOR TOPICAL USE ONLY

Locoid Solution Description

Locoid® (hydrocortisone butyrate) Solution, 0.1% contains the topical corticosteroid, hydrocortisone butyrate, a nonfluorinated hydrocortisone ester. It has the chemical name: 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate; the molecular formula: C25H36O6; the molecular weight: 432.54; and the CAS registry number: 13609-67-1.

Its structural formula is:

Each mL of Locoid Solution contains 1 mg of hydrocortisone butyrate in a vehicle consisting of anhydrous citric acid, glycerin, isopropyl alcohol (50% v/v), povidone, purified water, and sodium citrate.

Locoid Solution - Clinical Pharmacology

Topical corticosteroids share anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids.

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical c...