Lodoxamide
Class: Antiallergic Agents
- Mast-cell Stabilizers
ATC Class: S01GX05
VA Class: OP900
Chemical Name: N,N′-2-(chloro-5-cyano-m-phenylene)dioxamic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:2)
Molecular Formula: C11H6ClN3O6•2C4H11NO3
CAS Number: 63610-09-3
Brands: Alomide
Introduction
Mast-cell stabilizer.
Uses for Lodoxamide
Allergic Ocular Disorders
Symptomatic treatment of certain allergic ocular disorders including vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis (designated an orphan drug by FDA for such use).
Lodoxamide Dosage and Administration
Administration
Ophthalmic Administration
Apply topically to the eye as an ophthalmic solution. Not for injection. Not for subconjunctival injection or introduction directly into anterior chamber of the eye.
Avoid contamination of the solution container.
Dosage
Available as lodoxamide tromethamine; dosage expressed in terms of lodoxamide.
Pediatric Patients
Allergic Ocular Disorders
Ophthalmic
Children ≥2 years of age: 1 or 2 drops of a 0.1% solution in the affected eye(s) 4 times daily for up to 3 months.
Adults
Allergic Ocular Disorders
Ophthalmic
1 or 2 drops of a 0.1% solution in the affected eye(s) 4 times daily for up to 3 months.
Cautions for Lodoxamide
Contraindications
Known hypersensitivity to lodoxamide or any ingredient in the formulation.
Warnings/Precautions
General Precautions
Ocular Effects
Possible ocular burning or stinging upon installation. (See Advice to Patients.)
Specific Populations
Pregnancy
Category B.
Lactation
Not known whether lodoxamide is distributed into milk. Use with caution in nursing women.
Pediatric Use
Safety and efficacy not established in children <2 years of age.
Geriatric Use
No substantial differences in safety and efficacy relative to younger adults.
Common Adverse Effects
Ocular burning, stinging, discomfort.
Lodoxamide Pharmacokinetics
Absorption
Bioavailability
Plasma concentrations are undetectable following topical application to the eye.
Distribution
Extent
Not known whether lodoxamide is distributed into milk.
..