Lonafarnib

Generic name: lonafarnib [ LOE-na-FAR-nib ]
Brand name: Zokinvy
Dosage form: oral capsule (50 mg; 75 mg)
Drug class:Miscellaneous metabolic agents

Medically reviewed by Drugs.com on Jan 11, 2021. Written by Cerner Multum.

What is lonafarnib?

Lonafarnib is for use in people with certain rare genetic conditions that cause premature and rapid aging. Lonafarnib is for use in adults and children at least 12 months old whose bodies have reached a certain size (a body surface area of 0.39 square meters).

Lonafarnib is used to lower the risk of death in people with Hutchinson-Gilford Progeria Syndrome (HGPS).

Lonafarnib is also used to treat certain types of Progeroid Laminopathies that are "processing-deficient."

lonafarnib is not for use in people with non-HGPS Progeroid Syndromes or with Progeroid Laminopathies that are "processing-proficient."

Lonafarnib may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You should not use lonafarnib if you are also using certain other medicines.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with lonafarnib. Your doctor may change your treatment plan if you also use:

• midazolam;

• St. John's wort;

• phenobarbital or other barbiturate medicine;

• an antibiotic or antifungal medicine;

• antiviral medicine to treat HIV or hepatitis C;

• cancer medicine;

• cholesterol medicine (atorvastatin, lovastatin, or simvastatin);

• heart or blood pressure medicine;

• seizure medicine; or

• steroid medicine.

You may need to stop using lonafarnib for 10 to 14 days before and 2 days after using certain other medicines. Do not stop taking lonafarnib without your doctor's advice.

Tell your doctor if you have ever had:

• kidney disease; or

• eye problems.

Lonafarnib may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

lonafarnib may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because lonafarnib can harm an...