Loncastuximab tesirine
Generic name: loncastuximab tesirine [ LON-kas-TUX-i-mab-TES-ir-een ]
Brand name: Zynlonta
Dosage form: intravenous injection (10 mg)
Drug class:Miscellaneous antineoplastics
What is loncastuximab tesirine?
Loncastuximab tesirine is used to treat large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.
Loncastuximab tesirine may also be used for purposes not listed in this medication guide.
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms (cough, tiredness, weakness, body aches), headache, trouble breathing, or skin wounds with pain, redness, warmth, or swelling.
Before taking this medicine
Tell your doctor if you have ever had:
liver problems; or
an infection.
Loncastuximab tesirine can harm an unborn baby if the mother or the father is using loncastuximab tesirine.
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 9 months after your last dose.
If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.
Tell your doctor right away if a pregnancy occurs.
It may be harder for a man to get a woman pregnant while using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 3 months after your last dose.
How should I use loncastuximab tesirine?
Loncastuximab tesirine is injected into a vein by a healthcare provider, usually once every 3 weeks.
You may be given other medications to help prevent serious side effects. Keep using these medicines for as long as your doctor has prescribed.
You may get infections more easily, even serious or fatal infections. You will need frequent medical tests, and further doses may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your loncastuximab tesirine injection.
What happens if I overdose?
In a medical setting an overdose would be treated quickly.
What should I avoid while using loncastuximab tesirine?
Loncastuximab tesirine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are out...
