Lopinavir and ritonavir

Generic name: lopinavir and ritonavir [ loe-PIN-a-vir-and-ri-TOE-na-veer ]
Brand name: Kaletra
Dosage forms: oral liquid (400 mg-100 mg/5 mL); oral tablet (100 mg-25 mg; 200 mg-50 mg)
Drug class:Protease inhibitors

Medically reviewed by Drugs.com on Mar 31, 2021. Written by Cerner Multum.

What is lopinavir and ritonavir?

Lopinavir and ritonavir is a combination antiviral medicine used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). lopinavir and ritonavir is not a cure for HIV or AIDS.

Lopinavir and ritonavir is for use in adults and children who are at least 14 days old.

Lopinavir and ritonavir may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Lopinavir and ritonavir can cause a serious heart problem. Call your doctor at once if you have fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out).

Tell your doctor if you have signs of liver or pancreas problems: loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Before taking this medicine

You should not use lopinavir and ritonavir if you have ever had a severe allergic reaction to lopinavir or ritonavir.

Some medicines can cause unwanted or dangerous effects when used with lopinavir and ritonavir. Your doctor may change your treatment plan if you also use:

• apalutamide;

• alfuzosin;

• cisapride;

• colchicine;

• dronedarone;

• elbasvir/grazoprevir;

• lomitapide;

• lurasidone, pimozide;

• ranolazine;

• rifampin;

• lovastatin, simvastatin;

• triazolam, or oral midazolam;

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