Lorbrena

Generic name:lorlatinib [ lor-LAT-i-nib ]
Drug class:Multikinase inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Mar 10, 2021.

What is Lorbrena?

Lorbrena is prescription medicine used to treat a certain type of non-small cell lung cancer that has spread to other parts of the body.

Lorbrena is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene.

Warnings

Do not take Lorbrena if you take certain other medicines called strong CYP3A inducers. Ask your healthcare provider for a list of these medicines if you are not sure.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

To make sure Lorbrena is safe for you, tell your doctor if you have ever had:

• heart problems, such as "AV block" (unless you have a pacemaker);

• lung disease, breathing problems;

• liver disease;

• depression;

• seizures; or

• high cholesterol or triglycerides (a type of fat in the blood).

Lorlatinib can harm an unborn baby or cause birth defects if the mother or the father is using Lorbrena.

• If you are a woman, do not use Lorbrena if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

• If you are a man, use effe...