Lotronex
Generic name:alosetron (oral) [ a-LO-ze-tron ]
Drug class:Serotoninergic neuroenteric modulators
What is Lotronex?
Lotronex blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools (bowel movements) through the intestines.
Lotronex is used to treat severe, chronic irritable bowel syndrome (IBS) in women with diarrhea as the main symptom for at least 6 months. Alosetron should be used only by women who have tried other IBS treatments without success. Alosetron not been shown to be effective in men with IBS.
Lotronex is not a cure for irritable bowel syndrome. After you stop taking this medicine, your symptoms may return within 1 week.
Warnings
Lotronex should be used only by women with severe irritable bowel syndrome and diarrhea as the main symptom.
Do not start taking Lotronex if you are constipated. You also should not take alosetron if you take another medicine called fluvoxamine (Luvox).
Serious or fatal side effects on the stomach and intestines have occurred in some people taking Lotronex. In rare cases, Lotronex has caused severe constipation, or ischemic colitis (caused by reduced blood flow to the intestines).
Stop taking this medicine and call your doctor right away if you have: new or worsening constipation, stomach pain, bright or dark red blood in your stools, or bloody diarrhea. You may need to permanently discontinue this medicine if you have these side effects.
Do not start taking Lotronex if you are constipated. You also should not take taking this medicine if you take another medicine called fluvoxamine (Luvox).
If you stop taking this medicine for any reason, do not start taking it again without your doctor's advice.
Before taking this medicine
Do not take Lotronex if you have ever had any of the following conditions:
constipation (especially if it is your main IBS symptom);
a history of severe or ongoing constipation;
obstruction or perforation of your intestines;
Crohn's disease, ulcerative colitis, or diverticulitis;
blood clots, or circulation problems affecting your intestines;
severe liver disease; or
a condition for which you also take fluvoxamine (Luvox).
Tell your doctor if you are pregnant or breastfeeding.
If you breastfeed while taking Lotronex, call your doctor if your baby shows signs of constipation or has bloody stools.
Lotronex is not approved for use by anyone younger than 18 years old.
How should I take Lotronex?
Take Lotronex exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Read al...
