Lufyllin-GG Solution
Generic name:dyphylline and guaifenesin
Dosage form: oral solution
Drug class:Antiasthmatic combinations
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
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On This Page
IN-0541-13 Rev. 1/09
The Lufyllin-GG brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Description
LUFYLLIN®-GG is a bronchodilator/expectorant combination available for oral administration as Oral Solution.
Each 15 mL (one tablespoonful) of Oral Solution contains:
| Dyphylline | 100 mg |
| Guaifenesin | 100 mg |
| Alcohol (by volume) | 17% |
Other ingredients: citric acid, FD&C Yellow No. 6, flavor (artificial), purified water, saccharin sodium, sodium citrate, sucrose.
Dyphylline is 7-(2,3-dihydroxypropyl)-theophylline, a white, extremely bitter, amorphous powder that is fully soluble in water and soluble in alcohol to the extent of 2g/100 mL. Dyphylline forms a neutral solution that is stable in gastrointestinal fluids over a wide range of pH.
Clinical Pharmacology
Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle.
Dyphylline in LUFYLLIN®-GG is well tolerated and produces l...
