Malathion

Dosage form: topical lotion
Drug class:Topical anti-infectives

Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.

Rx Only

For topical use only. Not for oral or ophthalmic use.

Malathion Description

Malathion lotion contains 0.005 g of Malathion per mL in a vehicle of isopropyl alcohol (78%), terpineol, dipentene, and pine needle oil. The chemical name of Malathion is (±) - [(dimethoxyphosphinothioyl) - thio] butanedioic acid diethyl ester. Malathion has a molecular weight of 330.36, represented by C10H19O6PS2, and has the following chemical structure:

Malathion - Clinical Pharmacology

Malathion is an organophosphate agent which acts as a pediculicide by inhibiting cholinesterase activity in vivo. Inadvertent transdermal absorption of Malathion has occurred from its agricultural use. In such cases, acute toxicity was manifested by excessive cholinergic activity, i.e., increased sweating, salivary and gastric secretion, gastrointestinal and uterine motility, and bradycardia (see OVERDOSAGE).

Because the potential for transdermal absorption of Malathion from Malathion lotion is not known at this time, strict adherence to the dosing instructions regarding its use in children, method of application, duration of exposure, and frequency of application is required.

Indications and Usage for Malathion

Malathion lotion is indicated for patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.

Contraindications

Malathion lotion is contraindicated for neonates and infants because their scalps are more permeable and may have increased absorption of Malathion. Malathion lotion should also not be used on individuals known to be sensitive to Malathion or any of the ingredients in the vehicle.

Warnings

1. Malathion lotion is flammable. The lotion and wet hair should not ...