Marquis

Generic name: ponazuril
Dosage form: FOR ANIMAL USE ONLY

Caution:

Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian.

For The Treatment Of Equine

Protozoal Myeloencephalitis (EPM) In Horses

For Oral Use Only

DESCRIPTION:

Marquis® (15% w/w ponazuril) Antiprotozoal Oral Paste is supplied in ready-to-use syringes containing 127 grams of paste. Each gram of paste contains 150 mg of ponazuril (15% w/w). Marquis (ponazuril) is designed to be delivered as an orally administered paste.

Each syringe barrel of Marquis (ponazuril) contains enough paste to treat one (1) 1,200 lb (544 kg) horse for seven (7) days, at a dose rate of 5 mg/kg (2.27 mg/lb) body weight. The plunger contains a dosage ring calibrated for a dose rate of 5 mg/kg (2.27 mg/lb) body weight and marked for horse weight from 600 to 1,200 lbs (272 to 544 kg). The syringe barrels are packaged in units of four with four reusable plungers. This package provides sufficient paste to treat one 1,200 lb (544 kg) horse for 28 days at a dose rate of 5 mg/kg (2.27 mg/lb) body weight.

Ponazuril is an anticoccidial (antiprotozoal) compound with activity against several genera of the phylum Apicomplexa.

CHEMICAL NOMENCLATURE AND STRUCTURE:

Ponazuril 1,3,5-Triazine-2,4,6(1H, 3H, 5H)-trione,1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl] phenoxy]phenyl]-(9CI)

CLINICAL PHARMACOLOGY:

The activity of ponazuril has been demonstrated in several Apicomplexans1-6. Lindsay, Dubey and Kennedy7 showed that the concentration of ponazuril necessary to kill Sarcocystis neurona in vitro was 0.1 to 1.0 µg/mL. Furr and Kennedy8 evaluated the pharmacokinetics of ponazuril in serum and CSF in normal horses treated daily at 5 mg/kg for 28 days. The time to peak serum concentration (Tmax) was 18.20 (±5.9) days and the maximum serum concentration (Cmax) was 5.59 (±0.92) µg/mL. The terminal elimination half-life for serum (calculated using Day 28 to 42 data) was 4.50 (±0.57) days. In CSF, Tmax was 15.40 (±7.9) days and C