Fusilev

Generic name:levoleucovorin calcium
Dosage form: injection, powder, lyophilized, for solution
Drug class:Antidotes

Medically reviewed by Drugs.com. Last updated on Nov 1, 2020.

Indications and Usage for Fusilev

Fusilev is indicated for:
• rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma.
• diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination in adult and pediatric patients.
• the treatment of adults with metastatic colorectal cancer in combination with fluorouracil.

Limitations of Use
Fusilev is not indicated for pernicious anemia and megaloblastic anemia secondary to the lack of vitamin B12, because of the risk of progression of neurologic manifestations despite hematologic remission.

Fusilev Dosage and Administration

Important Use Information

Fusilev is indicated for intravenous administration only. Do not administer intrathecally.

Co-adminstration of Fusilev with other agents

Due to the risk of precipitation, do not co-administer Fusilev with other agents in the same admixture.

Recommended Dosage for Rescue After High-Dose Methotrexate Therapy

The recommended dosage for Fusilev is based on a methotrexate dose of 12 grams/m2 administered by intravenous infusion over 4 hours. Twenty-four hours after starting the methotrexate infusion, initiate Fusilev at a dose of 7.5 mg (approximately 5 mg/m2) as an intravenous infusion every 6 hours.
Monitor serum creatinine and methotrexate levels at least once daily. Continue Fusilev administration, hydration, and urinary alkalinization (pH of 7 or greater) until the methotrexate level is below 5 x 10-8 M (0.05 micromolar). Adjust the Fusilev dose or extend the duration as